Can Selenium and CoQ10 supplementation slow down biological ageing?

New human study on ageing and the importance of sirtuins1 – gene regulating enzymes.

Increased SIRT1 Concentration Following Four Years of Selenium and Q10 Intervention Associated with Reduced Cardiovascular Mortality at 10-Year Follow-Up—Sub-Study of a Previous Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial

It is well-known that Selenium has many health benefits, and that supplementation is beneficial for people with insufficient levels of this essential trace element. It has anti-inflammatory and antioxidant properties and has been found to reduce oxidative stress induced by reactive oxygen species.

Coenzyme Q10 is present in the mitochondria and also helps regulate oxidative stress. CoQ10 supplementation has been shown to be specifically beneficial in the elderly, as the endogenous synthesis declines with age.

After four years of supplementation with combined Se and coenzyme Q10, we found SIRT1 concentration to be significantly increased, which was potentially mediated by miR-130a-3p downregulation, among other microRNAs, ensuing CV protection with a significant reduction in CV mortality. The importance of Se and coenzyme Q10 in the prevention of CVD and the role of SIRT1 in this context highlight the beneficial effects of SIRT1 on CV functions, suggesting SIRT as a target for the potential to prevent cardiovascular mortality.